Problem 3
What are the possible metabolic fates of pyruvate?
Problem 7
Why is the formation of fructose- \(1,6-\) bighosphate the committed step in glycolysis?
Problem 9
What is the metabolic advantage of having both hexokinase and glucokinase to phosphorylate glucose?
Problem 12
How does ATP act as an allosteric effector in the mode of action of phosphofructokinase?
Problem 19
Several of the enzymes of glycolysis fall into classes that we will see often in metabolism. What reaction types are catalyzed by each of the following: (a) Kinases (b) Isomerases (c) Aldolases (d) Dehydrogenases
Problem 20
What is the difference between an isomerase and a mutase?
Problem 23
Discuss the logic of the nature of the allosteric inhibitors and activators of glycolysis. Why would these molecules be used?
Problem 24
Many species have a third type of LDH subunit that is found predominantly in the testes. If this subunit, called \(C,\) were expressed in other tissues and could combine with the \(\mathrm{M}\) and \(\mathrm{H}\) subunits, how many LDH isozymes would be possible? What would their compositions be?
Problem 29
If lactic acid is the buildup product of strenuous muscle activity, why is sodium lactate often given to hospital patients intravenously?
Problem 30
What is the metabolic purpose of lactic acid production?
