Problem 2
How does a sporadic cancer differ from a Mendelian disease in terms of predicting risk of occurrence in the relatives of a patient?
Problem 3
What are the three basic cellular pathways that cancer disrupts?
Problem 4
What is metastasis, and why is it dangerous?
Problem 5
Explain the connection between cancer and control of the cell cycle.
Problem 6
List four characteristics of cancer cells.
Problem 7
Describe four ways that cancer can originate at the cell or tissue level.
Problem 8
Distinguish between a driver mutation and a passenger mutation.
Problem 9
Describe two abnormalities of chromosomes in cancer.
Problem 10
Explain how comparing mutations in cells from the same cancer type at different stages can reveal the sequence of genetic changes that drive the cancer.
Problem 11
How can classifying cancer genomically differ from classifying cancer histologically or by initial affected body part?
