Problem 12
Distinguish between a proto-oncogene and an oncogene.`
Problem 13
Describe two events that can activate an oncogene.
Problem 14
Explain why an oncogene is associated with a gain-of-function and a mutation in a tumor suppressor gene is associated with a loss-of-function.
Problem 16
What is the role of poor DNA repair in causing cancer?
Problem 18
Distinguish among mutations, altered gene expression, and epigenetic changes in cancer.
Problem 19
Explain why not all cancers affecting the same cell type respond the same way to a particular drug.
Problem 20
Describe an alternative to performing surgery to determine whether a metastatic tumor is responding to a new drug.
