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Quantitative noninvasive techniques are needed for routinely assessing symptoms of peripheral neuropathies, such as carpal tunnel syndrome (CTS). The article "A Gap Detection Tactility Test for Sensory Deficits Associated with Carpal Tunnel Syndrome" (Ergonomics, \(1995: 2588 - 2601\)) reported on a test that involved sensing a tiny gap in an otherwise smooth surface by probing with a finger; this functionally resembles many work-related tactile activities, such as detecting scratches or surface defects. When finger probing was not allowed, the sample average gap detection threshold for\(m = 8\)normal subjects was\(1.71\;mm\), and the sample standard deviation was\(.53\); for\(n = 10\)CTS subjects, the sample mean and sample standard deviation were\(2.53\)and\(.87\), respectively. Does this data suggest that the true average gap detection threshold for CTS subjects exceeds that for normal subjects? State and test the relevant hypotheses using a significance level of\(.01\).

Short Answer

Expert verified

where the probability can be found in the table in the appendix. Since

\(P = P(T \le - 2.46) = 0.013\)

do not reject null hypothesis at the given significance level. There is not enough evidence to claim that the true average for CTS subjects exceeds the true average for normal subjects.

Step by step solution

01

To find the test statistic value:

The hypotheses of interest are

\({H_0}:{\mu _1} - {\mu _2} = 0{\rm{ vs }}{H_a}:{\mu _1} - {\mu _2} < 0\)

where\({\mu _1}\)is the true average gap for normal subjects, and\({\mu _2}\)is the true average for CTS subjects.

Given two normal distributions, the random variable (standardized)

\(T = \frac{{\bar X - \bar Y - \left( {{\mu _1} - {\mu _2}} \right)}}{{\sqrt {\frac{{S_1^2}}{m} + \frac{{S_2^2}}{n}} }}\)

has approximately students\(t\)distribution with degrees of freedom\(\nu \), where\(\nu \)is

\(\nu = \frac{{{{\left( {\frac{{s_1^2}}{m} + \frac{{s_2^2}}{n}} \right)}^2}}}{{\frac{{{{\left( {s_1^2/m} \right)}^2}}}{{m - 1}} + \frac{{{{\left( {s_2^2/n} \right)}^2}}}{{n - 1}}}}\)

has to be rounded down to the nearest integer.

The test statistic value can be computed using the given value in the exercise as follows

\(\begin{array}{l}t = \frac{{\bar x - \bar y - \left( {{\mu _1} - {\mu _2}} \right)}}{{\sqrt {\frac{{s_1^2}}{m} + \frac{{s_2^2}}{n}} }} = \frac{{1.71 - 2.53}}{{\sqrt {\frac{{0.53}}{8} + \frac{{2.53}}{{0.87}}} }}\\ = \frac{{ - 0.82}}{{\sqrt {0.035 + 0.076} }} = \frac{{ - 0.82}}{{0.333}}\\ = - 2.46\end{array}\)

02

To find the degrees of freedom:

The degrees of freedom can be computed by the given formula

\(\nu = \frac{{{{\left( {\frac{{s_1^2}}{m} + \frac{{s_2^2}}{n}} \right)}^2}}}{{\frac{{{{\left( {s_1^2/m} \right)}^2}}}{{m - 1}} + \frac{{{{\left( {s_2^2/n} \right)}^2}}}{{n - 1}}}} = \frac{{{{(0.035 + 0.076)}^2}}}{{\frac{{{{0.035}^2}}}{7} + \frac{{0.076}}{9}}} = 15.085\)\(P = P(T \le - 2.46) = 0.013\)

and the round down to the nearest integer is the needed degrees of freedom

\(\nu = 15\)

Since the alternative hypothesis is\({H_a}:{\mu _1} - {\mu _2} < 0\), the corresponding\(P\)value is the probability to the left of\(t\)under the students\(T\)statistic with degrees of freedom 15 , therefore

where the probability can be found in the table in the appendix. Since

\(P = P(T \le - 2.46) = 0.013\)

do not reject null hypothesis at the given significance level. There is not enough evidence to claim that the true average for CTS subjects exceeds the true average for normal subjects.

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Most popular questions from this chapter

Which way of dispensing champagne, the traditional vertical method or a tilted beer-like pour,preserves more of the tiny gas bubbles that improve flavor and aroma? The following data was reported in the article โ€œOn the Losses of Dissolved \(C{O_2}\) during Champagne Servingโ€ (J. Agr. Food Chem., 2010: 8768โ€“8775)

\(\begin{array}{*{20}{c}}{ Temp \left( {^^\circ C} \right)}&{ Type of Pour }&n&{ Mean (g/L)}&{ SD }\\{18}&{ Traditional }&4&{4.0}&{.5}\\{18}&{ Slanted }&4&{3.7}&{.3}\\{12}&{ Traditional }&4&{3.3}&{.2}\\{12}&{ Slanted }&4&{2.0}&{.3}\\{}&{}&{}&{}&{}\end{array}\)

Assume that the sampled distributions are normal.

a. Carry out a test at significance level \(.01\) to decide whether true average\(C{O_2}\)loss at \(1{8^o}C\) for the traditional pour differs from that for the slanted pour.

b. Repeat the test of hypotheses suggested in (a) for the \(1{2^o}\) temperature. Is the conclusion different from that for the \(1{8^o}\) temperature? Note: The \(1{2^o}\) result was reported in the popular media

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Anorexia Nervosa (AN) is a psychiatric condition leading to substantial weight loss among women who are fearful of becoming fat. The article "Adipose Tissue Distribution After Weight Restoration and Weight Maintenance in Women with Anorexia Nervosa" (Amer. J. of ClinicalNutr., 2009: 1132-1137) used whole-body magnetic resonance imagery to determine various tissue characteristics for both an AN sample of individuals who had undergone acute weight restoration and maintained their weight for a year and a comparable (at the outset of the study) control sample. Here is summary data on intermuscular adipose tissue (IAT; kg).

Assume that both samples were selected from normal distributions.

a. Calculate an estimate for true average IAT under the described AN protocol, and do so in a way that conveys information about the reliability and precision of the estimation.

b. Calculate an estimate for the difference between true average AN IAT and true average control IAT, and do so in a way that conveys information about the reliability and precision of the estimation. What does your estimate suggest about true average AN IAT relative to true average control IAT?

It is well known that a placebo, a fake medication or treatment, can sometimes have a positive effect just because patients often expect the medication or treatment to be helpful. The article "Beware the Nocebo Effect" (New York Times, Aug. 12, 2012) gave examples of a less familiar phenomenon, the tendency for patients informed of possible side effects to actually experience those side effects. The article cited a study reported in The Journal of Sexual Medicine in which a group of patients diagnosed with benign prostatic hyperplasia was randomly divided into two subgroups. One subgroup of size 55 received a compound of proven efficacy along with counseling that a potential side effect of the treatment was erectile dysfunction. The other subgroup of size 52 was given the same treatment without counseling. The percentage of the no-counseling subgroup that reported one or more sexual side effects was 15.3 %, whereas 43.6 % of the counseling subgroup reported at least one sexual side effect. State and test the appropriate hypotheses at significance level .05 to decide whether the nocebo effect is operating here. (Note: The estimated expected number of "successes" in the no-counseling sample is a bit shy of 10, but not by enough to be of great concern (some sources use a less conservative cutoff of 5 rather than 10).)

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Worker : 1 2 3 4

Conventional : .0011 .0014 .0018 .0022

Perforated : .0011 .0010 .0019 .0013

Worker: 5 6 7

Conventional : .0010 .0016 .0028

Perforated : .0011 .0017 .0024

Worker 8 9 10

Conventional : .0020 .0015 .0014

Perforated : .0020 .0013 .0013

Worker: 11 12 13

Conventional : .0023 .0017 .0020

Perforated : .0017 .0015 .0013

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