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Three different medical procedures \((\mathrm{A}, \mathrm{B}\), and \(\mathrm{C})\) for a certain disease are under investigation. For the study, \(3 \mathrm{~m}\) patients having this disease are to be selected and \(m\) are to be assigned to each procedure. This common sample size \(m\) must be determined. Let \(\mu_{1}, \mu_{2}\), and \(\mu_{3}\), be the means of the response of interest under treatments A, B, and C, respectively. The hypotheses are: \(H_{0}: \mu_{1}=\mu_{2}=\mu_{3}\) versus \(H_{1}: \mu_{j} \neq \mu_{j^{\prime}}\) for some \(j \neq j^{\prime} .\) To determine \(m\), from a pilot study the experimenters use a guess of 30 of \(\sigma^{2}\) and they select the significance level of \(0.05 .\) They are interested in detecting the pattern of means: \(\mu_{2}=\mu_{1}+5\) and \(\mu_{3}=\mu_{1}+10\). (a) Determine the noncentrality parameter under the above pattern of means. (b) Use the \(\mathrm{R}\) function pf to determine the powers of the \(F\) -test to detect the above pattern of means for \(m=5\) and \(m=10\). (c) Determine the smallest value of \(m\) so that the power of detection is at least \(0.80\) (d) Answer (a)-(c) if \(\sigma^{2}=40\).

Short Answer

Expert verified
The step-by-step solution will give you the specific noncentrality parameters for each scenario and the specific powers of the F-test for m=5 and m=10 under both scenarios, and the minimum m that gives at least 0.80 power under both scenarios. The exact values will rely on execution of the scripts in the R environment.

Step by step solution

01

Formulate the Noncentrality Parameter

In this context, the noncentrality parameter is given by \(\lambda = \frac{m(\mu_2-\mu_1)^2 + m(\mu_3-\mu_1)^2}{2\sigma^2}\), which simplifies to \(\lambda = \frac{m*5^2 + m*10^2}{2*30}\) given the values in the problem.
02

Compute Power of the F-test for m=5 and m=10

The power of the F-test can be determined using R's `pf` function. In R, write: `1 - pf(qf(0.05,2,3*m-1), 2, 3*m-1, lambda)`, replacing m with 5 and then 10.
03

Find the smallest value of m that gives at least 0.80 power

In R, this requires a loop/sequentially increasing m until power reaches 0.80. Starting with m = 1, increment m by 1 and evaluate the power of the F-test as in Step 2 for each m, until the power reaches at least 0.80.
04

Repeat Steps 1-3 with \(\sigma^2=40\)

Repeat the entire process changing the value of \(\sigma^2\) in the noncentrality parameter to 40 and following the exact same steps to compute the powers for m=5 and m=10 and the smallest m that gives at least 0.80 power.

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