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To illustrate Exercise 4.2.24, let \(X_{1}, X_{2}, \ldots, X_{9}\) and \(Y_{1}, Y_{2}, \ldots, Y_{12}\) represent two independent random samples from the respective normal distributions \(N\left(\mu_{1}, \sigma_{1}^{2}\right)\) and \(N\left(\mu_{2}, \sigma_{2}^{2}\right) .\) It is given that \(\sigma_{1}^{2}=3 \sigma_{2}^{2}\), but \(\sigma_{2}^{2}\) is unknown. Define a random variable that has a \(t\) -distribution that can be used to find a \(95 \%\) confidence interval for \(\mu_{1}-\mu_{2}\).

Short Answer

Expert verified
The required random variable, having a \(t\)-distribution, is defined as \(t = \frac{\bar{X} - \bar{Y}}{\sqrt{s_{p}^{2} \left(\frac{1}{n} + \frac{1}{m}\right)}}\) with \(n + m - 2 = 19\) degrees of freedom. The 95% confidence interval for \(\mu_{1}-\mu_{2}\) is \((\bar{X} - \bar{Y}) \pm t_{0.025, 19} \sqrt{s_{p}^{2} \left(\frac{1}{n} + \frac{1}{m}\right)}\).

Step by step solution

01

Compute sample means

Given the two independent samples \(X_{1}, X_{2}, \ldots, X_{9}\) and \(Y_{1}, Y_{2}, \ldots, Y_{12}\), calculate their respective sample means: \[\bar{X} = \frac{1}{9}(X_{1} + X_{2} + \ldots + X_{9})\] \[\bar{Y} = \frac{1}{12}(Y_{1} + Y_{2} + \ldots + Y_{12})\] These represent the sample estimates for \(\mu_1\) and \(\mu_2\) respectively.
02

Estimate variances

Use the relationship between the variances, \(\sigma_1^2 = 3\sigma_2^2\), and compute the pooled variance. Given there is no direct information about \(\sigma_2^2\), replace \(\sigma_1^2\) with \(s_1^2\) and \(\sigma_2^2\) with \(s_2^2\) in the equation. The estimates for the population variances \(\sigma_1^2\) and \(\sigma_2^2\) are \(s_1^2\) and \(s_2^2\) respectively. So, \(s_1^2 = 3s_2^2\). This equation can be used in the formula for pooled variance.
03

Compute the t-statistic

The t-statistic can now be computed as follows: \[t = \frac{\bar{X} - \bar{Y}}{\sqrt{s_{p}^{2} \left(\frac{1}{n} + \frac{1}{m}\right)}}\] where \(n=9\) and \(m=12\) are the respective sample sizes and \(s_{p}^{2}\) is the pooled variance. This will have a t-distribution with \(n + m - 2 = 9 + 12 - 2 = 19\) degrees of freedom.
04

Define the Confidence Interval

The 95% confidence interval for \(\mu_{1}-\mu_{2}\) can be defined as follows: \[(\bar{X} - \bar{Y}) \pm t_{0.025, 19} \sqrt{s_{p}^{2} \left(\frac{1}{n} + \frac{1}{m}\right)}\] where \(t_{0.025, 19}\) is the t-score corresponding to a 95% confidence level with 19 degrees of freedom.

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Most popular questions from this chapter

Verzani (2014), page 323 , presented a data set concerning the effect that different dosages of the drug AZT have on patients with HIV. The responses we consider are the p24 antigen levels of HIV patients after their treatment with AZT. Of the \(20 \mathrm{HIV}\) patients in the study, 10 were randomly assign the dosage of \(300 \mathrm{mg}\) of AZT while the other 10 were assigned \(600 \mathrm{mg}\). The hypotheses of interest are \(H_{0}: \Delta=0\) versus \(H_{1}: \Delta \neq 0\) where \(\Delta=\mu_{600}-\mu_{300}\) and \(\mu_{600}\) and \(\mu_{300}\) are the true mean p24 antigen levels under dosages of \(600 \mathrm{mg}\) and \(300 \mathrm{mg}\) of AZT, respectively. The data are given below but are also available in the file aztdoses. rda. \begin{tabular}{|l|llllllllll|} \hline \(300 \mathrm{mg}\) & 284 & 279 & 289 & 292 & 287 & 295 & 285 & 279 & 306 & 298 \\ \hline \(600 \mathrm{mg}\) & 298 & 307 & 297 & 279 & 291 & 335 & 299 & 300 & 306 & 291 \\ \hline \end{tabular} (a) Obtain comparison boxplots of the data. Identify outliers by patient. Comment on the comparison plots. (b) Compute the two-sample \(t\) -test and obtain the \(p\) -value. Are the data significant at the \(5 \%\) level of significance? (c) Obtain a point estimate of \(\Delta\) and a \(95 \%\) confidence interval for it. (d) Conclude in terms of the problem.

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