Communication networks
For example, if a communication company wants to reduce its costs on communication links of a network, then the company could be interested in a spanning tree such that everybody can be linked with all other people and such that the company can reduce its costs as much as possible (by avoiding the possibility of creating simple circuits).
Roads between cities
For example, a company that needs to make sure that all towns in its neighborhood are connected by a paved road might be interested in a spanning tree if it wants to reduce the cost of paving those roads (or if the client was to reduce the costs). The costs can then be minimized, by making sure that there are no circuits (since a circuit will lead to an extra stretch of road to be paved, while there already would have been paved roads that could be used to travel between the two towns).