A safe zone check is pivotal in the N-Queens Problem to ensure that placing a queen on a given cell doesn't lead to conflicts. When trying to place a queen in a cell on the chessboard, a comprehensive check is performed to ascertain that:
- No other queen exists in the same row.
- No other queen shares the same column.
- No other queen occupies the same diagonal, both major and minor.
These checks are crucial because queens can attack each other if they are on the same line of movement. The algorithm looks at horizontal, vertical, and diagonal lines originating from the cell being considered for placement. If all these checks return negative, meaning no threats are detected, the cell is deemed a 'safe zone' for placing the queen. If at any during these checks a conflict is identified, the algorithm proceeds to try the next possible cell or backtracks if no further possibilities exist in the current step.