Problem 11
All of the following are believed to contribute to the stability of the deoxy or \(\mathrm{T}\) conformation of hemoglobin except A. a larger ionic radius of six-coordinated ferrous ion as compared to five- coordinated ion. B. unstrained steric interaction of His \(\mathrm{F} 8\) with the porphyrin ring when iron is above the plane. C. interactions between the \(\mathrm{FG}\) corner of one subunit and the \(\mathrm{C}\) helix of the adjacent subunit. D. ionic interactions.
Problem 12
When hemoglobin is converted from the deoxy (T) form to oxyhemoglobin (R), A. it becomes more acidic and releases protons. B. carbamino formation is promoted. C. binding of 2,3 -bisphosphoglycerate (BPG) is favored. D. bound NO is transferred to glutathione. E. all of the above.
Problem 13
One of the adaptations to high altitude is an increase in the concentration of BPG. What effect does this have on a saturation versus \(p \mathrm{O}_{2}\) curve? Why does increasing [BPG] increase the delivery of \(\mathrm{O}_{2}\) to tissues?
Problem 14
What would be the likely order of appearance of various immunoglobulins in response to a viral pathogen introduced via the nasal passages and subsequently into the blood?
