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Malignant cancer cells have all of the following properties except A. unregulated cell division. B. inhibition of angiogenesis. C. resistance to apoptosis. D. cellular immortality. E. ability to metastasize.

Short Answer

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A. unregulated cell division B. inhibition of angiogenesis C. resistance to apoptosis D. cellular immortality E. ability to metastasize Answer: B. inhibition of angiogenesis

Step by step solution

01

Understanding Malignant Cancer Cells

Malignant cancer cells are cells that grow uncontrollably and can invade nearby tissues or spread to other parts of the body through the bloodstream or lymphatic system. They have several properties which make them different from normal cells.
02

Analyzing Option A

Option A states that malignant cancer cells exhibit unregulated cell division. This is true because they no longer respond to the usual signals that regulate cell growth and division. As a result, they are able to divide uncontrollably, forming a mass of abnormal cells known as a tumor. Thus, this option is not the correct answer.
03

Analyzing Option B

Option B states that malignant cancer cells inhibit angiogenesis. However, this is incorrect because they actually promote angiogenesis, which is the formation of new blood vessels. This allows the tumor to have a supply of nutrients and oxygen, enabling it to grow and survive. Therefore, this option is the correct answer.
04

Analyzing Option C

Option C states that malignant cancer cells exhibit resistance to apoptosis. Apoptosis is the natural process of programmed cell death that occurs when a cell is no longer needed or becomes damaged. Malignant cancer cells often develop mechanisms to avoid apoptosis, allowing them to survive and continue dividing despite being damaged. This property is accurate for malignant cancer cells, therefore it's not our answer.
05

Analyzing Option D

Option D states that malignant cancer cells exhibit cellular immortality. This is accurate because cancer cells can avoid the natural process of cellular aging, known as senescence, and continue to divide indefinitely, thereby making them virtually immortal. This is a property of malignant cancer cells, so this option is not the correct answer.
06

Analyzing Option E

Option E states that malignant cancer cells have the ability to metastasize. Metastasis is the process by which cancer cells leave the primary tumor site and spread to other parts of the body through the bloodstream or lymphatic system. Malignant cancer cells can invade nearby tissues and spread to distant sites, making this property valid for malignant cancer cells. Thus, this option is also not the correct answer. In conclusion, the correct answer is: B. inhibition of angiogenesis.

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Most popular questions from this chapter

Human papillomavirus (HPV) is a causative factor in over \(95 \%\) of cervical cancers. Other viruses such as Epstein-Barr, Kaposi's sarcoma-associated herpes virus, and hepatitis B virus also are known to cause cancer. For this to happen, viral genes that promote entry into Sphase or that promote resistance to apoptosis must become incorporated into the host cell DNA in a host cell that also survives the viral infection. If the viral gene within the host DNA is then overexpressed in an unregulated manner, it is a viral oncogene. The Epstein-Barr protein binds to the cellular Rb-binding pocket and displaces E2F from Rb. The effect would be to A. require that \(R b\) be phosphorylated. B. stall the cell cycle in the G_phase. C. increase the transcription of gene products for S-phase proteins. D. inhibit the action of cyclin-dependent kinases (Cdks). E. inhibit apoptosis.

Apoptotic death of a cell may include all of the following except A. Iysis of the cell membrane with inflammation. B. activation of enzymes called caspases. C. phagocytosis. D. binding of a ligand in the extracellular environment to a plasma membrane receptor. E. transfer of toxic molecules from the mitochondria to cytoplasm through protein-induced outer membrane permeabilization.

The property of cellular immortality refers to a cell's ability to A. grow new blood vessels. B. invade through the basement membrane of its tissue. C. resist apoptosis. D. continue to divide without limit to the number of cell generations. E. grow tumors at multiple sites.

Cyclin-dependent kinases (Cdks) A. occur only in the M phase. B. are always inactivated by phosphorylation. C. typically phosphorylate proteins on tyrosine residues. D. in addition to binding cyclin, require other modifications for activity. E. that phosphorylate \(\mathrm{Rb}\) (retinoblastoma sensitivity) protein inhibit the synthesis of S-phase proteins.

Human papillomavirus (HPV) is a causative factor in over \(95 \%\) of cervical cancers. Other viruses such as Epstein-Barr, Kaposi's sarcoma-associated herpes virus, and hepatitis B virus also are known to cause cancer. For this to happen, viral genes that promote entry into Sphase or that promote resistance to apoptosis must become incorporated into the host cell DNA in a host cell that also survives the viral infection. If the viral gene within the host DNA is then overexpressed in an unregulated manner, it is a viral oncogene. A viral protein could bind to cellular \(\mathrm{P} 53\) and promote its degradation. P53, which is an inducer of apoptosis, A. is activated by kinases located in chromatin. B. increases the transcription of several pro-apoptotic genes for Bd- 2 protcins. C. concentration is normally low because it is subject to ubiquitination. D. concentration may be increased by acetylation. E. all of the above.

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