Question

ATP synthase (also known as complex \(V\) ) consists of two domains, \(F_{1}\) and \(F_{0}\) A. \(\mathrm{F}_{1}\) and \(\mathrm{F}_{\mathrm{o}}\) are both integral membrane protein complexes of the outer membrane. B. \(F_{1}\) domain provides a channel for translocation of protons across the membrane. C. \(F_{1}\) binds ATP but not ADP. D. \(F_{1}\) domain catalyzes the synthesis of ATP. E. Only the \(F_{0}\) domain contains more than one subunit.

Short answer

A. F₁ and F₀ are both integral membrane protein complexes of the outer membrane. B. The F₁ domain provides a channel for translocation of protons across the membrane. C. F₁ binds ATP but not ADP. D. The F₁ domain catalyzes the synthesis of ATP. E. Only the F₀ domain contains more than one subunit. Answer: D. The F₁ domain catalyzes the synthesis of ATP.

Step-by-step solution

Statement A

Determine if F₁ and F₀ are both integral membrane protein complexes of the outer membrane. This statement is incorrect. The F₀ domain is an integral membrane protein complex of the inner mitochondrial membrane, and the F₁ domain projects into the mitochondrial matrix.

Statement B

Determine if the F₁ domain provides a channel for translocation of protons across the membrane. This statement is incorrect. The F₀ domain forms the channel for proton translocation, not the F₁ domain.

Statement C

Determine if F₁ binds ATP but not ADP. This statement is incorrect. The F₁ domain is capable of binding both ATP and ADP as it catalyzes the synthesis of ATP from ADP and inorganic phosphate (Pi).

Statement D

Determine if the F₁ domain catalyzes the synthesis of ATP. This statement is accurate. The F₁ domain is responsible for catalyzing the synthesis of ATP from ADP and inorganic phosphate (Pi) using the energy provided by the proton gradient.

Statement E

Determine if only the F₀ domain contains more than one subunit. This statement is incorrect. Both F₁ and F₀ domains have multiple subunits. The F₁ domain consists of α, β, γ, δ, and ϵ subunits, while the F₀ domain contains subunits a, b, and c. Based on the analysis, the correct answer is: - D. F₁ domain catalyzes the synthesis of ATP.