Chapter 13: Problem 5
Calmodulin is A. a nonspecific kinase. B. a protein that binds \(\mathrm{Ca}^{2+}\). C. a second messenger. D. an activator of nitric oxide synthase. E. a protein channel that facilitates the influx of \(\mathrm{Ca}^{2+}\).
Chapter 13: Problem 5
Calmodulin is A. a nonspecific kinase. B. a protein that binds \(\mathrm{Ca}^{2+}\). C. a second messenger. D. an activator of nitric oxide synthase. E. a protein channel that facilitates the influx of \(\mathrm{Ca}^{2+}\).
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Get started for freeThe ErbB/HER family of receptor tyrosine kinase genes are linked to many different types of human cancers. Overexpression of any of these genes would lead to an increase in the various receptors. ErbB2 encodes the HER2 protcin. This receptor does not bind any known extracellular growth factor, but it does form dimers with other growth-factor-bound HER receptors. Even modest overexpression of HER2 can alter normal cell growth regulation. Ras protein is a critical regulator in cell proliferation, and its activity is enhanced by activated tyrosine kinase. Elements of its action include all of the following except A. formation of cyclic GMP. B. adaptor proteins binding to phosphorylated ryrosines on receptor tyrosine kinase. C. recruitment and stimulation of Ras-activating protein. D. exchange of GDP for GTP on the Ras protein. E. initiation of a cascade in which several kinases are activated sequentially by phosphorylation.
How does elevation of cyclic AMP in eukaryotic cells lead to altered transcription of certain genes?
Intracellular receptors A. usually bind hydrophobic ligands. B. may be located either in the cytosol or nucleus in unbound state. C. when bound to their ligand, regulate gene transcription. D. when bound to their ligand, function as dimeric complexes binding to specific DNA sequences. E. all of the above.
The type of intercellular signaling in which one cell can communicate with another over long distances is called A. autocrine. B. endocrine. C. juxtacrine. D. paracrine. E. synaptic.
The ErbB/HER family of receptor tyrosine kinase genes are linked to many different types of human cancers. Overexpression of any of these genes would lead to an increase in the various receptors. ErbB2 encodes the HER2 protcin. This receptor does not bind any known extracellular growth factor, but it does form dimers with other growth-factor-bound HER receptors. Even modest overexpression of HER2 can alter normal cell growth regulation. Which of the following statements about receptor tyrosine kinases is correct? A. The catalytic domain is on the N-terminal end. B. Activation of the kinase requires ATP. C. Growth factor binding to the receptor triggers dimerization which activates the kinase activity. D. Active tyrosine kinase can phosphorylate other proteins but not itself. E. All of the above.
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