Question

In chromatography, why is the optimal flow rate greater if the stationary phase particle size is smaller?

Short answer

The solution is

the smaller the particle, the faster the equilibrium between the stationary and mobile phases is achieved.

Step-by-step solution

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In this job, we will explain why the ideal flow rate in chromatography is higher when the stationary phase particle size is lower.

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Representative diffusion coefficients at 289K are shown in Table 23-1:

- As the size of the diffusing particle and the viscosity of the fluid both rise, the friction coefficient increases.

- Some larger molecules diffuse slower than small ones due to their vast radius.

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As a result, the smaller the particle, the faster the equilibrium between the stationary and mobile phases is achieved.

- As seen in Table 23-1, tiny molecules have a greater diffusion coefficient.