Question

The initial reaction in Problem 29-52, conversion of two molecules of acetyl CoA to one molecule of acetoacetyl CoA, is a Claisen reaction. Assuming that there is a base present, show the mechanism of the reaction.

Short answer

The mechanism of the reaction when two molecule of acetyl CoA conversion to one molecule for acetoacetyl CoA is called Claisen reaction can be shown. The reaction of carbonyl occur in frequency biological reaction.

Step-by-step solution

Claisen condensation mechanism via thiol ester

The mechanism of Claisen condensation can be drawn as,

Ketone bodies biosynthesis

The first step is ketone bodies biosynthesis. The condensation of 2 molecules of acetyl CoA to 1 molecule of aceto acetyl through an enzyme. There is a transference of thiolane by acetyl CoA. It is an claisen condensation type and shown as,