Question

How might you use a Suzuki–Miyaura reaction to prepare the biarylcompounds below? In each case, show the two potential reactionpartners.

Short answer

(a)

(b)

(c)

Step-by-step solution

Suzuki–Miyaura reaction

Suzuki miyaura reaction is an organic reaction, classified as a cross coupling reaction, where the coupling partners are boronic acid and an organohalide and the catalyst is a palladium complex.

Preparing Bi-aryl compounds by Suzuki miyaura reaction

The Suzuki- Miyaura reaction is Pd-catalyzed coupling reaction between an aromatic boronic acid and an aromatic vinyl halide. Two possible coupling reaction can yield the target product.

(a)

Preparation of Bi-aryl (a)

(b)

Preparation of Bi-aryl (b)

(c)

Preparation of Bi-aryl (c)