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Chapter 23: Q37E (page 783)

The amino acid leucine is biosynthesized from α-ketoisovalerate by the following sequence of steps. Show the mechanism of each.

Short Answer

Expert verified

The synthesis of leucine takes place from α-ketoisovalerate.

Step by step solution

01

Given sequence

The given reaction sequence is as follows,

02

Mechanism

Following are the steps involved in the process of synthesis of Leucine is,

  1. Aldol type reaction.
  2. Oxidation of alcohol with help of NAD+
  3. Decarboxylation
  4. Condensation with NH3 followed by reducing the desired product.

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Most popular questions from this chapter

Azlactones are important starting materials used in the synthesis of dehydro a-aminoacids. They react with aldehydes to form an intermediate that is hydrolyzed under acidic conditions to give the final amino acid product. Provide the structure of the intermediate and propose a mechanism for its formation.

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