Chapter 22: 58E (page 752)
How would you synthesize the following compounds from cyclohexanone?
More than one step may be required.
Short Answer
a)
b)
c)
d)
e)
f)
Chapter 22: 58E (page 752)
How would you synthesize the following compounds from cyclohexanone?
More than one step may be required.
a)
b)
c)
d)
e)
f)
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Get started for freeAmino acids can also be prepared by a two-step sequence that involves HellโVolhardโZelinskii reaction of a carboxylic acid followed by treatment with ammonia. Show how you would prepare leucine, (CH3)2CHCH2CH(NH2)CO2H, and identify the mechanism of the second step.
How could you use a malonic ester synthesis to prepare the following compound?
Fill in the reagents aโc that are missing from the following scheme:
Draw a resonance structure of the acetonitrileanion,
andaccount for the acidity of nitriles.
How many acidic Hydrogens does each of the molecules listed in Problem 22-1 have? Identify them.
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