Question

Fill in the reagents a–c that are missing from the following scheme:

Short answer

The reagents are:

(a) NaOC₂H₅/CH₃I

(b) H₃O⁺/Heat ,and

(c) LDA/CH₃I.

Step-by-step solution

  Acidic hydrogens in ketones

The alpha hydrogens in ketones are acidic in nature. The acidic protons will be removed in reaction with a strong base, and a carbanion intermediate will be formed. This carbanion intermediate on reaction with an alkyl halide forms a new C-C bond.

The given reaction is,

The given equation

Reagents

The reagents used in the reaction are,

The given chemical reaction