Chapter 28: Q 21E (page 963)
Question: Human brain natriuretic peptide (BNP) is a small peptide of 32 amino acids used in the treatment of congestive heart failure. How many nitrogen bases are present in the DNA that codes for BNP?
The nitrogen bases in the DNA that codes for BNP are 192.
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Question: Give an mRNA sequence that will code for the synthesis of mentenkephalin.
Tyr-Gly-Gly-Phe-Met
Melamine, used as a fire retardant and a component of the writing surface of white boards, can be prepared from s-trichlorotriazine through a series of SNAr reactions with ammonia. The first substitution takes place rapidly at room temperature. The second substitution takes place near 100 °C, and the third substitution requires even higher temperature and pressure. Provide an explanation for this reactivity.
Question: Give an mRNA sequence that will code for the synthesis of angiotensin II
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Question: Amine bases in nucleic acids can react with alkylating agents in typical SN2 reactions. Look at the following electrostatic potential maps, and tell which is the better nucleophile, guanine or adenine. The reactive positions in each are indicated.
If the DNA coding sequence -CAA-CCG-GAT- were miscopied during replication and became -CGA-CCG-GAT-, what effect would there be on the sequence of the protein produced?
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