Question

Draw the mechanism for the third reaction in glycolysis—the reaction of fructose-6-phosphate with ATP to form fructose-1,6-bisphosphate.

Short answer

The conversion of fructose 6-phosphate to fructose 1,6- bisphosphate is one of the phosphoryl transfer reactions. The reaction is irreversible under physiological conditions. This reaction is catalyzed by phosphofructokinase. The rate of the reaction depends on the activity of an enzyme.

Step-by-step solution

Step-by-Step SolutionStep 1: Conversion of fructose-6-phosphate with ATP to form fructose-1, 6-bisphosphate

The conversion of fructose 6-phosphate to fructose 1,6- bisphosphate is one of the phosphoryl transfer reactions. The reaction is irreversible under physiological conditions. This reaction is catalyzed by phosphofructokinase. The rate of the reaction depends on the activity of an enzyme.

Mechanism of the conversion

In the given transformation lone pair of oxygen of fructose 6-phosphate attacks the phosphorus of ATP molecule so that fructose-6-phosphate is converted to fructose-1, 6-bisphosphate.

The mechanism of the reaction is as follows;

Glycolysis (reaction 3)