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Chapter 24: Q46P (page 1126)

What are four possible fates of pyruvate in a mammalian cell?

Short Answer

Expert verified

The answer is,

Alanine Lactate Acetyl-CoA Oxaloacetate

Step by step solution

01

Pyruvate ion

The Pyruvate ion is an anion containing three carbon, three oxygen and three hydrogen atoms. The structure of pyruvate is as shown below.

Pyruvate

02

Explanation

The pyruvate can be converted to alanine (transamination), oxaloacetate (carboxylation), lactate (reduction) and acetyl- CoA (by the pyruvate dehydrogenase complex).

Alanine Lactate Acetyl-CoA Oxaloacetate

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Most popular questions from this chapter

Which reactions in the citric acid cycle form a product with a new asymmetric center?

In some brain cancer cells, a mutated form of isocitrate dehydrogenase, instead of catalyzing the oxidation of the secondary alcohol of isocitrate, catalyzes the reduction of \({\bf{\alpha }}\)-ketoglutarate. Draw the product of the reaction.

Palmitic acid is a 16-carbon saturated fatty acid. How many molecules of acetyl-CoA are formed from one molecule of palmitic acid?

A student is trying to determine the mechanism for a reaction that uses ATP to activate a carboxylate ion, which reacts with a thiol. If the carboxylate ion attacks the gamma- phosphorous of ATP, the reaction products are the thioester, ADP, and phosphate. However, whether it attacks the alpha-phosphorous or the beta-phosphorous of ATP cannot be determined from the reaction products because the thioester, AMP, and pyrophosphate would be the products in both reactions. The mechanisms can be distinguished by a labelling experiment in which the enzyme, the carboxylate ion, ATP, and radioactively labelled pyrophosphate are incubated, and then the ATP is isolated. If the isolated ATP is radioactive, the attack occurs on the alpha-phosphorous. If it is not radioactive, an attack occurs on the beta- phosphorous. Explain these conclusions.

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