Logout Open In App
Open In App
Warning: foreach() argument must be of type array|object, bool given in /var/www/html/web/app/themes/studypress-core-theme/template-parts/header/mobile-offcanvas.php on line 20

Chapter 23: Q8P (page 1076)

Draw structures that show the similarity between the decarboxylation of the pyruvate–TPP intermediate and the decarboxylation of a \(\beta \)-keto acid.

Short Answer

Expert verified

Pyruvate decarboxylation is a reaction where a carboxylate group is removed and hydrogen is added. This reaction converts pyruvate to acetyl CoA.

Step by step solution

01

Pyruvate decarboxylation

Pyruvate decarboxylation is a reaction where a carboxylate group is removed and hydrogen is added. This reaction converts pyruvate to acetyl CoA.

02

Beta- keto acid decarboxylation

During this reaction an enol intermediate is formed by proton transfer from the carboxylic acid group to the carbonyl oxygen atom of the ketone. So ketone from in this reaction.

03

Structures showing similarity in decarboxylation of pyruvate and beta- keto acid

In the mechanism of the two above reactions the structures showing similarity are:

Here it can be seen that the electron delocalization is occurring in same manner.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Start your free trial

Over 30 million students worldwide already upgrade their learning with Vaia!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

Instead of adding to the 4a position and protonating N-5, the thiolate ion could have added to the 10a position and protonated N-1. (The numbering system is on page 1071.) Why is addition to the 4a position favored? (Hint:Which nitrogen is a stronger base?)

Question: Name the coenzymes that

a. allow electrons to be delocalized.

b. are oxidizing agents.

c. provide a strong base.

d.donate one-carbon groups

Question:The glycine cleavage system is a group of four enzymes that together catalyze the following reaction:

glycine+THF→glycinecleavagesystemN5,N10-methylene-THF+CO2

Use the following information to determine the sequence of reactions carried out by the glycine cleavage system:

a. The first enzyme is a PLP-requiring decarboxylase.

b. The second enzyme is aminomethyltransferase. This enzyme has a lipoate coenzyme.

c. The third enzyme synthesizes N6,N10-methylene-THF and also forms NH4

d. The fourth enzyme is an FAD-requiring enzyme.

e.The cleavage system also requires NAD.

Question:A fatty acid (a long straight-chain carboxylic acid with an even number of carbons) is metabolized to acetyl- CoA, which can then enter the citric acid cycle to be further metabolized (Section 24.9). A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. Propionyl-CoA cannot enter the citric acid cycle. Two coenzyme-requiring enzymes are needed to convert it to succinyl-CoA, a compound that can enter the citric acid cycle. Write the two enzyme-catalyzed reactions and include the names

of the required coenzymes.

Question: How do the structures of tetrahydrofolate and aminopterin differ?
See all solutions

Recommended explanations on Chemistry Textbooks

Chemical Analysis

Read Explanation

Ionic and Molecular Compounds

Read Explanation

Inorganic Chemistry

Read Explanation

Physical Chemistry

Read Explanation

Chemical Reactions

Read Explanation

Chemistry Branches

Read Explanation
View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.

Sign-up for free