Question

propose a mechanism for the conservation of mevalonic acid to mevalonyl pyrophosphate?

Short answer

Two ATP-dependent phosphorylation events are required for the conversion of mevalonic acid to mevalonyl pyrophosphate, as shown below.

Step-by-step solution

Mevalonate pathway

The mevalonate route, also known as the isoprenoid pathway or the HMG-CoA reductase pathway, is a critical metabolic system that helps the body burn fat.

Mevalonic acid to mevalonyl phosphate

Acetoacetyl-CoA is formed by combining two acetyl-CoA molecules. HMG-CoA is formed as a result of a second condensation (3-hydroxy-3- methyl-glutaryl-CoA). (R)-mevalonate is the product of the reduction of HMG-CoA.

Formation of mevalonyl phosphate

Mevalonyl phosphate to mevalonyl pyrophosphate

Reductase for CoA IPP is formed by phosphorylating and decarboxylating the MVA that has been generated this way. Mevalonate kinase initially phosphorylates mevalonate-5-pyrophosphate, then phosphomevalonate kinase (PMK) completes the process.

Formation of mevalonyl pyrophosphate