Chapter 26: Q1P (page 1159)
In acidic solutions, nucleosides are hydrolyzed to a sugar and a heterocyclic base. Propose a mechanism for this reaction.
Chapter 26: Q1P (page 1159)
In acidic solutions, nucleosides are hydrolyzed to a sugar and a heterocyclic base. Propose a mechanism for this reaction.
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Get started for freeHuman immunodeficiency virus (HIV) is the retrovirus that causes AIDS. AZT was one of the first drugs designed to interfere with retroviral DNA synthesis. When cells take up AZT, they convert it to AZT-triphosphate. Explain how AZT interferes with DNA synthesis.
Why is the codon a triplet rather than a doublet or a quartet?
Which cytosine in the following sense strand of DNA could cause the most damage to the organism if it is deaminated?
A-T-G-T-C-G-C-T-A-A-T-C
Why does DNA not unravel completely before replication begins?
The amino acid sequences of peptide fragments obtained from a normal protein were compared with those obtained from the same protein synthesized by a defective gene. They were found to differ in only one peptide fragment. Their amino acid sequences are shown here:
Normal: Gln-Tyr-Gly-Thr-Arg-Tyr-Val
Mutant: Gln-Ser-Glu-Pro-Gly-Thr
a. What is the defect in DNA?
b. It was later determined that the normal peptide fragment is an octapeptide with a C-terminal Val-Leu. What is the C-terminal amino acid of the mutant peptide?
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