Chapter 15: Q70P (page 735)
What reagent should be used to carry out the following reaction?
Short Answer
The reagent used is benzoyl chloride
Chapter 15: Q70P (page 735)
What reagent should be used to carry out the following reaction?
The reagent used is benzoyl chloride
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Get started for freeDraw the structure for each of the following:
\(\begin{array}{}a.{\rm{ phenyl acetate}}\\b.{\rm{ }}\gamma {\rm{ - caprolactam}}\\c.{\rm{ sodium formate}}\\d.{\rm{ N - benzylethanamide}}\\e.{\rm{ }}\gamma {\rm{ - methylcaproic acid}}\\f.{\rm{ }}\beta {\rm{ - bromobutyramide}}\\g.{\rm{ ethyl 2 - chloropentanoate}}\\h.{\rm{cyclohexanecarbonyl chloride}}\\i.{\rm{ }}\alpha {\rm{ - chlorovaleric acid}}\\\end{array}\)
Problem:Show how each of the following esters could be prepared using a carboxylic acid as one of the startingmaterials:
a. methyl butyrate (odor of apples) b. octyl acetate (odor of oranges)
Problem:Show how each of the following esters could be prepared using a carboxylic acid as one of the startingmaterials:
a. methyl butyrate (odor of apples) b. octyl acetate (odor of oranges)
When treated with an equivalent of methanol, compound A, with the molecular formula C4H6Cl2O, forms the compound whose 1H NMR spectrum is shown here. Identify compound A.
Write the mechanism for the acid-catalyzed reaction of an amide with an alcohol to form an ester.
Catalytic antibodies catalyze a reaction by forcing the conformation of the substrate in the direction of the transition state. The synthesis of antibody is carried out in the presence of a transition state analog-a stable molecule that structurally resembles the transition state. This causes an antibody to be generated that recognizes and binds to the transition state, thereby stabilizing it. For example, the following transition state analog has been used to generate a catalytic antibody that catalyzes the hydrolysis of structurally similar ester:
a. Draw a possible transition state for the hydrolysis of the reaction.
b. The following transition state analog is used to generate a catalytic antibody for the catalysis of ester hydrolysis. Draw the structure of an ester whose rate of hydrolysis would be increased by this catalytic antibody.
c. Design a transition state analog that catalyzes amide hydrolysis at the amide group indicated.
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