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There are two kinds of aldolases. Class I aldolases are found in animals and plants, where class II aldolases are found in fungi, algae and some bacteria. Only class I aldolases form an imine. Class II aldolases have a metal ion (Zn2+) at the active site. The mechanism for catalysis by class I aldolases was described in section 22.13. propose a mechanism for catalysis by class II aldolases.

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01

Catalysis

The catalysis is the process of increasing the rate of reactions by carried out in the presence of a catalyst. The catalyst will increase the rate of the reaction by decreasing the activation energy of the reactants.

02

Explanation

The class I aldolases use a protonated imine as a site to which electrons can be delocalized. The class II aldolases use a metal ion complexed with the carbonyl group as a site to which electrons can be delocalized.

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