Chapter 21: Q53P (page 1027)
Aspartame (its structure is on page 1007) has a pI of 5.9. Draw its prevailing form at physiological pH (7.4).
Short Answer
Structure of aspartame at =7.4 is shown below:
Structure of aspartame at =7.4
Chapter 21: Q53P (page 1027)
Aspartame (its structure is on page 1007) has a pI of 5.9. Draw its prevailing form at physiological pH (7.4).
Structure of aspartame at =7.4 is shown below:
Structure of aspartame at =7.4
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Get started for freea. Why is the pKaof the glutamate side chain greater than the pKaof the aspartate side chain?
b. Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
Show the steps in the synthesis of the tetrapeptide in problem 34, using Merrifieldโs method.
Explain the order of elution (with a buffer of pH 4) of the following pairs of amino acids through a column packed with Dowex 50 (Figure 21.3):
a. aspartate before serine c. valine before leucine
b. serine before alanine d. tyrosine before phenylalanine
Cells can also convert a-keto acids into amino acids, but because the reagents organic chemists use for this reaction are not available in cells, they carry out this reaction by a different mechanism
(a) What amino acid is obtained from the reductive amination of each of the following metabolic intermediates in a cell by reductive amination?
(b) What amino acids are obtained from the same metabolic intermediates when the amino acids are synthesized in the laboratory?
Draw the tetrapeptide Ala-Thr-Asp-Asn and indicate the peptide bonds.
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