Chapter 21: Q4P (page 993)
Do any other amino acids in Table 21.2 have more than one asymmetric center?
Short Answer
Isoleucine is the only other amino acid that has more than one asymmetric center.
Chapter 21: Q4P (page 993)
Do any other amino acids in Table 21.2 have more than one asymmetric center?
Isoleucine is the only other amino acid that has more than one asymmetric center.
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Get started for freeTreatment of a polypeptide with 2-mercaptoethanol yields two polypeptides with the following primary structures:
Val-Met-Tyr-Ala-Cys-Ser-Phe-Ala-Glu-Ser
Ser-Cys-Phe-Lys-Cys-Trp-Lys-Tyr-Cys-Phe-Arg-Cys-Ser
Treatment of the original intact polypeptide with chymotrypsin yields the following peptides:
1. Ala, Glu, Ser 3. Tyr, Val, Met 5. Ser, Phe, 2 Cys, Lys, Ala, Trp
2. 2 Phe, 2 Cys, Ser 4. Arg, Ser, Cys 6. Tyr, Lys
Determine the positions of the disulfide bridges in the original polypeptide.
a. How many different octapeptides can be made from the 20 naturally occurring amino acids?
b. How many different proteins containing 100 amino acids can be made from the 20 naturally occurring amino acids?
Reaction of a polypeptide with carboxypeptidase A releases Met. The polypeptide undergoes partial hydrolysis to give the following peptides.
What is the sequence of the polypeptide?
1. Ser, Lys, Trp4. Leu, Glu, Ser 7. Glu, His 10. Glu, His, Val
2. Gly, His, Ala 5. Met, Ala, Gly8. Leu, Lys, Trp11. Trp, Leu, Glu
3. Glu, Val, Ser 6. Ser, Lys, Val 9. Lys, Ser 12. Ala, Met
Draw the resonance contributors of the peptide bond in the less stable configuration.
Identify the location and type of charge on the hexapeptide Lys-Ser-Asp-Cys-His-Tyr at each of the following pH values:
a. pH = 1 b. pH = 5 c. pH = 7 d. pH = 12
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