Chapter 21: Q36P (page 1012)
Show the steps in the synthesis of the tetrapeptide in problem 34, using Merrifield’s method.
Short Answer
The answer is,
Reaction
Chapter 21: Q36P (page 1012)
Show the steps in the synthesis of the tetrapeptide in problem 34, using Merrifield’s method.
The answer is,
Reaction
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Get started for freeCells can also convert a-keto acids into amino acids, but because the reagents organic chemists use for this reaction are not available in cells, they carry out this reaction by a different mechanism
(a) What amino acid is obtained from the reductive amination of each of the following metabolic intermediates in a cell by reductive amination?
(b) What amino acids are obtained from the same metabolic intermediates when the amino acids are synthesized in the laboratory?
a. How many different octapeptides can be made from the 20 naturally occurring amino acids?
b. How many different proteins containing 100 amino acids can be made from the 20 naturally occurring amino acids?
a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is 70%.
b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is 80%?
a. Why is the pKaof the glutamate side chain greater than the pKaof the aspartate side chain?
b. Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
Draw the resonance contributors of the peptide bond in the less stable configuration.
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