Question

a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is 70%.

b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is 80%?

Short answer

The answer is:

a. 5.8%

b. 4.4%

Step-by-step solution

Step-by-Step Solution Step 1: Amino acids

The yield of production of each substance is calculated in percentages. If the initial yield and the rate of formation on the addition of each substrate are given, the yield can be calculated in each step easily.

Subpart (a)

The overall yield of bradykinin when the yield for the addition of each amino acid to the chain is 70% is calculated as shown below.

70% ; 49% ; 34%; 24% ; 17% ; 12% ; 8.2% ; 5.8%

It is given that the yield is 70 % on the addition of each amino acid. So the calculation is based on the 70% of each 70%.

Subpart (b)

Theoverall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is 80% is calculated as shown below.

80% ; 64% ; 51% ; 41% ; 33% ; 26% ; 21% ; 17% ; 13% ; 11% ; 8.6% ; 6.9% ; 5.5% ; 4.4%

It is given that the yield is 80 % on the addition of each amino acid. So the calculation is based on the 80% of each 80%.