Chapter 22: Q68P-F (page 1204)
Question:Show how you would use an aldol, Claisen, or another type of condensation to make each compound
f.
Short Answer
Answer
Two methods to obtain product:
Chapter 22: Q68P-F (page 1204)
Question:Show how you would use an aldol, Claisen, or another type of condensation to make each compound
f.
Answer
Two methods to obtain product:
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Get started for freeAcid-catalyzed halogenation is synthetically useful for converting ketones to α,β-unsaturated ketones, which are useful in Michael reactions (Section 22-18). Propose a method for converting cyclohexanone to cyclohex-2-en-1-one, an important synthetic starting material.
Show the products of the reactions of these carboxylic acids with before and after hydrolysis.
The Knoevenagel condensation is a special case of the aldol condensation in which an active methylene compound reacts with an aldehyde or ketone, in the presence of a secondary amine as a basic catalyst, to produce a new C=C. Show the starting materials that made each of these by a Knoevenagel condensation.
Propose mechanisms for the two Dieckmann condensations just shown.
The following compounds can be synthesized by aldol condensations, followed by further reactions. (In each case, work backward from the target molecule to an aldol product, and show what compounds are needed for the condensation.)
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