Question

Show how you would convert the following starting materials into the target compound. You may use any additional reagents you need.

Short answer

Multistep synthesis forms an important part of organic reactions. It is a reaction where the starting material is transformed into a final product through several reactions.

Step-by-step solution

Multistep synthesis

Multistep synthesis forms an important part of organic reactions. It is a reaction where the starting material is transformed into a final product through several reactions.

Reaction of alkynes

Alkynes undergo several reactions, and one among those is the deprotonation. The deprotonation of alkynes gives rise to alkynes when sodium amide is used as a reagent.

Conversion of the following starting materials into the target compound

Benzyl bromide reacts with acetylene in the presence of sodium amide to form an anion. The reaction can be given as:

The generated anion reacts with the carbonyl group of the aldehyde, followed by acid-catalyzed dehydration in the presence of sulphuric acid and heat. This is followed by the incorporation of meta-chloroperoxybenzoic acid (mCPBA) to create the target molecule. The reaction can be given as: