Chapter 27: Problem 16
What is the meaning of the alpha as it is used in \(\alpha\)-amino acid?
Chapter 27: Problem 16
What is the meaning of the alpha as it is used in \(\alpha\)-amino acid?
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Get started for freeA chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric \(\mathrm{H}_{2}\) receptors. In the development of this drug, a cyano group was added to the substituted guanidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain.
Draw zwitterion forms of these amino acids. (a) Valine (b) Phenylalanine (c) Glutamine
Both norepinephrine and epinephrine are synthesized from the same protein- derived amino acid. From which amino acid are they synthesized? What types of reactions are involved in their biosynthesis?
Why is Arg often referred to as a basic amino acid? Which other two amino acids are also basic amino acids?
For aspartic and glutamic acids, the isoelectric point occurs at a \(\mathrm{pH}\) where the net charge on the two carboxyl groups is \(-1\) and balances the charge of \(+1\) on the \(\alpha\)-amino group. Calculate pI for these amino acids.
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