Chapter 23: Problem 3
Write structural formulas for these amines. (a) Isobutylamine (b) Triphenylamine (c) Diisopropylamine
Chapter 23: Problem 3
Write structural formulas for these amines. (a) Isobutylamine (b) Triphenylamine (c) Diisopropylamine
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Get started for freeStarting with 3-nitroaniline, show how to prepare the following compounds. (a) 3-Nitrophenol (b) 3 -Bromoaniline (c) 1,3 -Dihydroxybenzene (resorcinol) (d) 3-Fluoroaniline (e) 3-Fluorophenol (f) 3 -Hydroxybenzonitrile
The procedure of methylation of amines and thermal decomposition of quaternary ammonium hydroxides was first reported by Hofmann in 1851, but its value as a means of structure determination was not appreciated until 1881 , when he published a report of its use to determine the structure of piperidine. Following are the results obtained by Hofmann. Piperidine 1,4 -Pentadiene (a) Show that these results are consistent with the structure of piperidine (Section 23.1). (b) Propose two additional structural formulas (excluding stereoisomers) for \(\mathrm{C}_{5} \mathrm{H}_{11} \mathrm{~N}\) that are also consistent with the results obtained by Hofmann.
identify all carbon chiral centers in coniine, nicotine, and cocaine.
Several diamines are building blocks for the synthesis of pharmaceuticals and agrochemicals. Show how both 1,3 -propanediamine and 1,4-butanediamine can be prepared from acrylonitrile.
Sotalol is a \(\beta\)-adrenergic blocker used to treat certain types of cardiac arrhythmias. Its hydrochloride salt is marketed under several trade names, including Betapace. Following is a retrosynthetic analysis. (a) Propose a synthesis for sotalol from aniline. (b) Is sotalol chiral? If so, which of the possible stereoisomers are formed in this synthesis?
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