Question

Question: Draw the product formed when each starting material is treated with LDA in THF solution at –78⁰C.

Short answer

Answer

The products formed when each starting material is treated with LDA are shown below.

Step-by-step solution

Definition of LDA

LDA is a non-nucleophilic strong base that abstracts protons from the least hindered C-H group.

Function of LDA

Due to its bulky nature due to the attached isopropyl groups with the nitrogen atom, it always acts as a base. It withdraws protons from the least hindered site.

The products of the given reaction are:

Reaction of a

Reaction of b

Reaction of c

Reaction of d