Chapter 5: Q.53 (page 208)
Label the stereogenic centers in paclitaxel, the chapter-opening anticancer drug, as R or S.
Short Answer
The stereogenic centers of paclitaxel are labeled as follows:
Chapter 5: Q.53 (page 208)
Label the stereogenic centers in paclitaxel, the chapter-opening anticancer drug, as R or S.
The stereogenic centers of paclitaxel are labeled as follows:
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Get started for freeDraw the structure of (S)-citalopram, a drug used to treat depression and anxiety that is much more potent than its R enantiomer.
citalopram
Locate the stereogenic centers in each Newman projection and label each center as R or S.
a.
b.
Locate the stereogenic center in each compound and draw both enantiomers.
a.
b.
c.
A limited number of chiral compounds having no stereogenic centers exist. For example, although A is achiral, constitutional isomer B is chiral. Make models and explain this observation. Compounds containing two double bonds that share a single carbon atom are called allenes. Locate the allene in the antibiotic mycomycin and decide whether mycomycin is chiral or achiral.
Draw both enantiomers of clopidogrel (trade name Plavix), a drug given to prevent the formation of blood clots in persons who have a history of stroke or coronary artery disease. Plavix is sold as a single enantiomer with the S configuration. Which enantiomer is Plavix?
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