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Chapter 5: Q.36 (page 205)

a) Locate the stereogenic centers in the ball-and-stick model of ezetimibe (trade name Zetia), a cholesterol-lowering drug. (b) Label each stereogenic center as R or S.

Short Answer

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Step by step solution

Meaning of stereogenic centers

A stereogenic center is a point in a molecule in which one carbon atom is bonded to four different groups of atoms. This carbon atom is considered to be asymmetrical in nature.

By interchanging any group on the asymmetrical carbon, it leads to the formation of a stereoisomer.

Stereogenic centers in ezetimibe

The structure of the ezetimibe molecule is shown below:

It has three stereocenters, as shown in the above structure.

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Most popular questions from this chapter

If the two stereogenic centers of a compound are R,S in configuration, what are the R,S assignments for its enantiomer and two diastereomers?

Indicate a plane of symmetry for each molecule that contains one. A molecule may require rotation around a carbon-carbon bond to see the plane of symmetry.