Question

What product is formed in the Suzuki coupling of A and B? This reaction was a key step in the synthesis of losartan, a drug used to treat hypertension.

Short answer

Answer

Step-by-step solution

Suzuki reaction

Numerous coupling reactions are present, and Suzuki reactions are categorized as coupling reactions. Suzuki reactions are conducted with the help of palladium catalysts.

Lozartan

Another name for the medication Lozartan is Cozaar. It is consumed through the mouth and can cure several conditions such as blood pressure, heart failure, etc.

Product formed in the Suzuki coupling of A and B

Compound A, an organic halide, reacts with compound B, an organoborane in the presence of $\mathrm{Pd}{\left(\mathrm{OAc}\right)}_2$and NaOH, to give rise to the stereospecific product. The reaction can be given as follows.

Suzuki coupling of A and B