Chapter 29: Q60. (page 1196)
Draw the organic products formed in each reaction.
Chapter 29: Q60. (page 1196)
Draw the organic products formed in each reaction.
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Get started for freeWhat steps are needed to convert A to L-dopa, an uncommon amino acid that is effective in treating Parkinsonโs disease? These steps are the key reactions in the first commercial asymmetric synthesis using a chiral transition metal catalyst. This process was developed at Monsanto in 1974.
Draw the structure of each peptide. Label the N-terminal and C-terminal amino acids and all amide bonds.
a. ValโGlu
b. GlyโHisโLeu
c. MโAโTโT
Besides the Boc and Fmoc protecting groups used in peptide synthesis, amines can also be protected by reaction with benzyl chloroformate (). Draw the structure of the product formed by reaction of alanine with benzyl chloroformate
Use the given experimental data to deduce the sequence of an octapeptide that contains the following amino acids: Ala, Gly (2 equiv), His (2 equiv), Ile, Leu and Phe. Edman degradation cleaves Gly from the octapeptide, and carboxypeptidase forms Leu and a heptapeptide. Partial hydrolysis forms the following fragments: Ile-His-Leu, Gly, Gly-Ala-Phe-His, and Phe-His-Ile.
Draw the mechanism for the reaction that removes an Fmoc group from an amino acid under the following conditions:
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