Chapter 29: Q51. (page 1194)
Draw the structure for each peptide:
(a) Phe–Ala;
(b) Gly–Gln;
(c) Lys–Gly;
(d) R-H
Short Answer
c.
d.
Chapter 29: Q51. (page 1194)
Draw the structure for each peptide:
(a) Phe–Ala;
(b) Gly–Gln;
(c) Lys–Gly;
(d) R-H
c.
d.
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Get started for freeL-thyroxine, a thyroid hormone and oral medication used to treat thyroid hormone deficiency, is an amino acid that does not exist in proteins. Draw the zwitterionic form of L-thyroxine.
Draw all the steps in the synthesis of each peptide from individual amino acids:
Gly-Ala;
Glutamic acid is synthesized by the following reaction sequence. Draw a stepwise mechanism for Steps [1]–[3].
Another method to form a peptide bond involves a two-step process:
[1] Conversion of a Boc-protected amino acid to a p-nitrophenyl ester.
[2] Reaction of the p-nitrophenyl ester with an amino acid ester.
Why does a p-nitrophenyl ester “activate” the carboxy group of the first amino acid to amide formation?
Would a p-methoxyphenyl ester perform the same function? Why or why not?
Draw the organic products formed in each reaction.
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