Question

Devise a synthesis of the following dipeptide from amino acid starting materials.

Short answer

Protecting Group

Synthesis of Ala-Ser

Step-by-step solution

The given dipeptide

The given dipeptide has two amino acids, - alanine, and serine.

The structure of the required dipeptide is as shown:

Dipeptide

Protecting amine and carboxylic acid groups

The amine group in alanine is protected by using Boc(tertiary butyloxy carbonyl) reagent. The carboxylic acid group in serine is protected with bezyl alcohol as benzyl ester.

Synthesis

The amino acid alanine with a protected amino group, and the amino acid serine with a protected carboxylic acid group will react with each other and form the required dipeptide.

Protecting Groups

Synthesis of Ala-Ser