Chapter 29: Q2. (page 1156)
What form exists at the isoelectric point of each of the following amino acids: (a) valine; (b)leucine; (c)proline; (d) glutamic acid.
Short Answer
(a)

Chapter 29: Q2. (page 1156)
What form exists at the isoelectric point of each of the following amino acids: (a) valine; (b)leucine; (c)proline; (d) glutamic acid.
(a)
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Get started for freeGive the amino acid sequence of each peptide using the fragments obtained by partial hydrolysis of the peptide with acid.
Glutamic acid is synthesized by the following reaction sequence. Draw a stepwise mechanism for Steps [1]โ[3].
Another method to form a peptide bond involves a two-step process:
[1] Conversion of a Boc-protected amino acid to a p-nitrophenyl ester.
[2] Reaction of the p-nitrophenyl ester with an amino acid ester.
Why does a p-nitrophenyl ester โactivateโ the carboxy group of the first amino acid to amide formation?
Would a p-methoxyphenyl ester perform the same function? Why or why not?
Give the amino acid sequence of an octapeptide that contains the amino acids Tyr, Ala, Leu (2 equiv), Cys, Gly, Glu and Val, and forms the following fragments when partially hydrolyzed with HCl: Val-Cys-Gly-Glu, Ala-Leu-Tyr, and Tyr-Leu-Val-Cys.
Outline the steps needed to synthesize the tetrapeptideAlaโLeuโIleโGly using the Merrifield technique.
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