Chapter 29: Q14P (page 1152)
Question: Identify the nucleophile and the electrophile in the following acid–base reactions:
Short Answer
AlCl3is an electrophileand NH3 is a nucleophile.
The H+ of HBr is the electrophile and OH- is the nucleophile.
Chapter 29: Q14P (page 1152)
Question: Identify the nucleophile and the electrophile in the following acid–base reactions:
AlCl3is an electrophileand NH3 is a nucleophile.
The H+ of HBr is the electrophile and OH- is the nucleophile.
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Get started for freeDevise a synthesis of each peptide from amino acid starting materials: (a) Leu–Val; (b) Ala–Ile–Gly.
Consider two molecules of a tetrapeptide composed of only alanine residues. Draw the hydrogen bonding interactions that result when these two peptides adopt a parallel β-pleated sheet arrangement. Answer this same question for the antiparallel β-pleated sheet arrangement.
Glutathione, a powerful antioxidant that destroys harmful oxidizing agents in cells, is composed of glutamic acid, cysteine, and glycine, and has the following structure:
Glutathione
a. What product is formed when glutathione reacts with an oxidizing agent?
b. What is unusual about the peptide bond between glutamic acid and cysteine?
Devise a synthesis of each amino acid from acetaldehyde:
(a) Glycine;
(b) Alanine.
As shown in Mechanism 29.2, the final steps in the Edman degradation result in rearrangement of a thiazolinone to an N-phenylthiohydantoin. Draw a stepwise mechanism for this acid-catalyzed reaction.
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