Question

Question: What starting materials are needed to prepare each drug using reductive amination? Give all possible pairs of compounds when more than one route is possible.

a.

b.

Short answer

Answer

Step-by-step solution

Reduction amination

Reductive amination is the procedure to reduce aldehyde and ketone into amine by the use of reducing agents. The amines can be primary, secondary, or tertiary amines.

Reducing agents

The reducing agents are lithium aluminum hydride, sodium cyanoborohydride, and sodium borohydride. These reducing agents produce hydride that reduces the carbonyl compounds.

Explanation

a. The given amine compound is obtained by the reduction of ketone, as shown below.

Reduction of ketone in a

b. The given amine compound is obtained by the reduction of ketone, as shown below.

Reduction of ketone in b