Question

Question: Label the alkene in each drug as E or Z. Enclomiphene is one component of the fertility drug Clomid. Tamoxifen is an anticancer drug. Clavulanic acid is sold in combination with the antibiotic amoxicillin under the trade name Augmentin.

a

b.

c.

Short answer

Answer

a. E

b. Z

c. Z

Step-by-step solution

E or Z configuration

If the groups around the double bond are opposite to each other, the double bond is assigned E configuration, whereas if the groups are on the same side, the double bond is assigned Z configuration

Assigning E or Z configuration

a. The given compound is shown below:

Enclomiphene

The priority groups are present on different sides. Thus, the double

bond has an E configuration.

b. The given compound is shown below:

Tamoxifen

The priority groups are present on the same side. Thus, the double bond has Z configuration.

c. The given compound is shown below:

Clavulanic acid

The priority groups are present on the same side. Thus, the double bond has Z configuration.