Question

What acid chloride would be needed to prepare each of the following ketones from benzene using a Friedel–Crafts acylation?

Short answer

The reactions involving the replacement of a hydrogen atom of the benzene ring with an acyl group are termed as Friedel-Crafts acylation reactions.

In the Friedel-Crafts acylation reaction, the benzene is made to react with an acyl chloride $\left(RCOCl\right)$in presence of a Lewis acid catalyst.

Step-by-step solution

Friedel–Crafts acylation reaction

The reactions involving the replacement of a hydrogen atom of the benzene ring with an acyl group are termed as Friedel-Crafts acylation reactions.

In the Friedel-Crafts acylation reaction, the benzene is made to react with an acyl chloride $\left(RCOCl\right)$in presence of a Lewis acid catalyst.

Reaction of benzene with an acyl chloride

The reaction of benzene with an acid chloride is shown below.

The acyl chlorides required to prepare the given ketones

Replacing the benzene ring in the given ketones with the chlorine atom gives the corresponding acyl chlorides used in the synthesis of the given ketones.

a

b

c