Chapter 18: 39 P (page 722)
What products are formed when benzene is treated with each alkyl chloride and ?
Chapter 18: 39 P (page 722)
What products are formed when benzene is treated with each alkyl chloride and ?
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Get started for freeD is an intermediate in the synthesis of rosiglitazone (trade name Avandia), a drug used for type 2 diabetes. Suggest two different methods to prepare the ether in D by substitution reactions.
Draw all resonance structures for each compound and use the resonance structures to determine if the substituent has an electron-donating or electron-withdrawing resonance effect.
Question: Draw a stepwise mechanism for the following intramolecular reaction, which is used in the synthesis of the female sex hormone estrone.
Draw a stepwise mechanism for the sulfonation of an alkyl benzene such as A to form a substituted benzenesulfonic acid B. Treatment of B with base forms a sodium salt C that can be used as a synthetic detergent to clean away dirt (see Problem 3.22).
Rank the following compounds in order of increasing reactivity in electrophilic aromatic substitution.
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