Chapter 29: Q53P (page 1194)
Name each peptide using both the three-letter and one-letter abbreviations of the component amino acids.
a.
b.
Short Answer
- Gly-Asp-Glu and G-D-E.
- Ala-Gly-Arg and A-G-R.
Chapter 29: Q53P (page 1194)
Name each peptide using both the three-letter and one-letter abbreviations of the component amino acids.
a.
b.
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Get started for freeThe anti-obesity drug orlistat works by irreversibly inhibiting pancreatic lipase, an enzyme responsible for the hydrolysis of triacylglycerols in the intestines, so they are excreted without metabolism, inhibition occurs by reaction of orlistat with a serine residue of the enzyme, forming a covalently bound, inactive enzyme product. Draw the structure of the product formed during inhibition.
Explain why the pKaof the -NH3+group of an -amino acid is lower than the pKaof the ammonium ion derived from a amine . For example, pKaof the group of alanine is 9.87 but the pKaof is 10.63.
What types of stabilizing interactions exist between each of the following pairs of amino acids?
a. Ser and Tyr
b. Val and Leu
c. two Phe residues
After the peptide chain of collage has been formed, many of the proline residues are hydroxylated on one of the ring carbon atoms. Why is this process important for the triple helix of collagen?
Draw the products of each reaction.
(a)
(b)
(c)
(d)
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