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When young rats are placed on a completely fat-free diet, they grow poorly, develop a scaly dermatitis, lose hair, and soon die. These symptoms can be prevented if linoleate or plant material is included in the diet. What makes linoleate an essential fatty acid? Why can plant material be substituted?

Short Answer

Expert verified
Linoleate is essential for vital biological functions and plant material contains linoleic acid.

Step by step solution

01

Understanding Essential Fatty Acids

Essential fatty acids are types of fats that are crucial for biological processes but are not synthesized by the body, meaning they must be obtained through diet.
02

Role of Linoleate

Linoleate is a type of omega-6 essential fatty acid. It plays a critical role in maintaining the structure of cell membranes, producing signaling molecules, and regulating inflammation.
03

Symptoms of Deficiency

The symptoms observed in rats—poor growth, scaly dermatitis, hair loss, and death—are due to the deficiency of essential fatty acids, highlighting the critical biological roles of these fats.
04

Substitution with Plant Material

Plant materials can serve as a substitute for linoleate because many plant oils contain linoleic acid, which can provide the necessary essential fatty acids that the body needs.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Linoleate
Linoleate is a type of essential fatty acid that falls under the category of omega-6 fatty acids. It is important because the human body cannot produce it on its own, yet functions critically depend on it. Linoleate is necessary for maintaining the integrity and flexibility of cell membranes. Additionally, it is vital in the production of signaling molecules and in the regulation of inflammation in the body.

Without an adequate intake of linoleate, biological processes struggle, potentially leading to severe health complications. This is why it is imperative to include linoleate in the diet to ensure the proper functioning of various bodily systems.
Omega-6 Fatty Acids
Omega-6 fatty acids are a family of polyunsaturated fats essential for health. Like other essential nutrients, they cannot be synthesized by human cells, which is why they must be consumed through food. Alongside omega-3 fatty acids, omega-6 fatty acids play a key role in brain function and normal growth and development.

They are also important in maintaining bone health, regulating metabolism, and ensuring reproductive capability. Foods rich in omega-6 fatty acids include various plant oils, nuts, and seeds. It's important to maintain a balance of omega-3 to omega-6 intake in the diet, as an imbalance can lead to chronic inflammation and associated health issues.
Dietary Deficiency
Dietary deficiency occurs when a person's diet lacks essential nutrients needed for optimal health. In the context of essential fatty acids, a deficiency can have serious consequences. This is because essential fatty acids are involved in many crucial body functions. Young rats, for example, exhibit poor growth and develop scaly dermatitis when deprived of these fats, due to their significant role in cell structure and function. Humans might experience similar symptoms, such as skin problems, hair loss, and a weakened immune system. That's why obtaining a diet rich in essential fatty acids, like linoleate, is crucial to avoid these deficiency-related health issues.
Plant Oils
Plant oils are often excellent sources of essential fatty acids like linoleate. Many commonly used plant oils, such as safflower, sunflower, and corn oil, are rich in omega-6 fatty acids, making them perfect dietary supplements for these essential nutrients.

The extraction process of oil from seeds and nuts preserves the fatty acids within, allowing consumers to easily obtain the necessary nutrients through their diet. Integrating plant oils into your meals can be a delicious and simple way to ensure that you meet your dietary needs for essential fatty acids. Always aim for a variety of sources to promote a balanced intake of both omega-6 and omega-3 fatty acids.

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Most popular questions from this chapter

A researcher has prepared a solution that contains all the enzymes and cofactors necessary for fatty acid biosynthesis from added acetyl-CoA and malonyl-CoA. a. She then adds \(\left[2-{ }^{2} \mathrm{H}\right]\) acetyl-CoA (labeled with deuterium, the heavy isotope of hydrogen) and an excess of unlabeled malonyl- CoA as substrates. How many deuterium atoms incorporate into every molecule of palmitate? What are their locations? Explain. b. In a separate experiment, the researcher adds unlabeled acetyl-CoA and \(\left[2-{ }^{2} \mathrm{H}\right]\) malonyl-CoA as substrates. How many deuterium atoms incorporate into every molecule of palmitate? What are their locations? Explain.

After a person has ingested large amounts of sucrose, the body transforms the glucose and fructose that exceed caloric requirements to fatty acids for triacylglycerol synthesis. This fatty acid synthesis consumes acetyl-CoA, ATP, and NADPH. How do cells produce acetyl-CoA, ATP, and NADPH from glucose?

Patients treated with a statin drug generally exhibit a dramatic lowering of serum cholesterol. However, the amount of the enzyme HMG-CoA reductase present in cells can increase substantially. Suggest a simple explanation for this effect.

In the biosynthesis of complex lipids, components are assembled by transfer of the appropriate group from an activated donor. For example, the activated donor of acetyl groups is acetyl-CoA. For each of the following groups, give the form of the activated donor: a. phosphate; b. D-glucosyl; c. phosphoethanolamine; d. D-galactosyl; e. fatty acyl; f. methyl; g. the two-carbon group in fatty acid biosynthesis; h. \(\Delta^{3}\)-isopentenyl.

Using your knowledge of fatty acid biosynthesis, provide an explanation for the two experimental observations. a. A biochemist adds uniformly labeled \(\left[{ }^{14} \mathrm{C}\right]\) acetyl-CoA to a soluble liver fraction, which yields palmitate uniformly labeled with \({ }^{14} \mathrm{C}\). b. In a second experiment, the biochemist adds a trace of uniformly labeled \(\left.{ }^{[14} \mathrm{C}\right]\) acetyl-CoA in the presence of an excess of unlabeled malonyl-CoA to a soluble liver fraction, which yields palmitate labeled with \({ }^{14} \mathrm{C}\) only in C-15 and C-16.

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