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Membrane Self-Sealing Cellular membranes are selfsealing - if they are punctured or disrupted mechanically, they quickly and automatically reseal. What properties of membranes are responsible for this important festure?

Short Answer

Expert verified
Self-sealing is due to the hydrophobic interactions of phospholipids in the membrane.

Step by step solution

01

Understanding the Structure of Cellular Membranes

Cellular membranes are primarily composed of a phospholipid bilayer. Each phospholipid molecule has a hydrophilic (water-attracting) head and two hydrophobic (water-repelling) tails.
02

The Role of Hydrophobic Interactions

The hydrophobic tails of phospholipids avoid water and thus face each other inside the bilayer, forming a stable and self-assembling structure that is essential for the integrity of the membrane.
03

Understanding Self-Sealing Mechanism

When a membrane is punctured, the hydrophobic tails still strive to avoid water. This natural tendency causes phospholipids to quickly rearrange themselves at the puncture site, forming new interactions that heal the disruption.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Phospholipid Bilayer
Imagine cellular membranes as a protective bubble surrounding each cell in your body. This bubble is composed of a special double layer known as the phospholipid bilayer. A phospholipid is made up of two parts: a hydrophilic head and two hydrophobic tails. The heads love water and naturally point towards water-rich environments, like the cell's interior and exterior. On the other hand, the tails are not water-friendly and prefer to face each other. This clever arrangement establishes a watertight barrier crucial for maintaining the cell’s environment.
The bilayer's unique orientation also supports its role in self-sealing. When disrupted, the hydrophilic heads align towards water again, while the hydrophobic tails retreat inward. This coordinated rearrangement makes cellular membranes superb at quickly patching up any holes or tears, keeping cells intact.
Hydrophobic Interactions
Hydrophobic interactions play a central role in the self-sealing nature of cell membranes. These interactions stem from the hydrophobic tails of the phospholipids, which naturally avoid water. In the bilayer, these tails face each other, hiding from the aqueous surroundings both inside and outside of the cell. This behavior isn’t just about being shy; it's about ensuring stability and cohesion in the membrane.
When a break occurs in the membrane, the phospholipids' urgent shuffle to return their tails away from water results in a quick resealing. This fast-paced recovery is due to hydrophobic interactions that pull phospholipids back into alignment, minimizing exposure to water and restoring membrane integrity. It’s like a spontaneous puzzle-solving party where everyone knows exactly where they belong.
Cellular Membrane Structure
The cellular membrane structure is more than a simple shell; it's a dynamic, fluid mosaic model. Primarily made of a phospholipid bilayer, it also includes proteins, cholesterol, and carbohydrates. These components are not static; they float and move laterally, allowing the membrane to be flexible yet robust.
The structure itself is vital for functions like signaling, transport, and maintaining homeostasis. Proteins embedded within the bilayer act as gatekeepers, controlling what enters and exits the cell. Cholesterol adds rigidity and strength, while carbohydrates play roles in cell recognition and signaling. This composition ensures that the membrane not only protects but also interacts with the cell’s environment precisely.
  • Phospholipid bilayer: Watertight and self-sealing
  • Proteins: Regulate and transport
  • Cholesterol: Stability and fluidity
  • Carbohydrates: Recognition and signaling
With all these features working in harmony, the cellular membrane is a highly efficient and self-repairing unit. It's like a bustling little city with everyone and everything having a specific purpose, all while being able to adapt and fix itself on the go.

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Most popular questions from this chapter

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when phospholipids are suspended in water. The edges of these sheets close upon each other and undergo self-sealing to form vesicles (liposomes). a. What properties of lipids are responsible for this property of bilayers? Explain. b. What are the consequences of this property for the structure of biological membranes?

Predicting Membrane Protein Topology I Online bainformatics tools make hydropathy analysis easy if you know the amino acid sequence of a protein. At the Protein Data Bank (www?rosharg), the Protein Feature View displays additional information about a protein gleaned from other databases, such as Uniprot and SCOP2. A simple graphical view of a hydropathy plot created using a window of 15 residues shows hydrophobic regions in red and hydrophilic regions in blue. a. Looking only at the displayed hydropathy plots in the Protein Feature View, what predictions would you make about the membrane topology of these proteins: glycophorin A (PDB ID 1AFO), myoglobin (PDB ID \(1 \mathrm{MBO}\), and aquaporin (PDB ID 2B6O)? 1507 b. Now, refine your information using the ProtScale tools at the ExpASy bioinformatics resource portal. Each of the PDB Protein Feature Views was created with a UniProt Knowledgebsese ID. For glycophorin \(A\), the UniProtKB ID is P02724; for myoglobin, P02185; and for aquaporin, Q6J819. Go to the ExPASy portal (http://web.expasy orgLprotscale) and select the Kyte \& Doolittle hydropathy analysis option, with a window of 7 amino acids. Enter the UniProtKB ID for aquaporin (Q6JS19, which you can also get from the PDB's Protein Feature View page), then select the option to analyze the complete chain (residues 1 to 263). Use the default values for the other options and click Submit to get a hydropathy plot. Save a GIF image of this plot. Now repeat the analysis using a window of 15 amino acids. Compare the results for the 7 -residue and 15-residue window analyses. Which window size gives you a better signal-to-noise ratio? c Under what circumstances would it be important to use a narrower window?

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